Wednesday, January 20, 2010

Sleep disordered breathing in facioscapulohumeral muscular dystrophy

Sleep disordered breathing in facioscapulohumeral muscular dystrophy

Giacomo Della MarcaaCorresponding Author Information1email address, Roberto Frusciantea1, Serena Dittonia, Catello Vollonoab, Cristina Buccarellaa, Elisabetta Iannacconea, Monica Rossic, Emanuele Scaranod, Tommaso Pirrontie, Alessandro Cianfonif, Salvatore Mazzaa, Pietro A. Tonaliac, Enzo Ricciac

Received 20 March 2009; received in revised form 5 May 2009; accepted 13 May 2009. published online 08 June 2009.


Facioscapulohumeral muscular dystrophy (FSHD) is one of the most frequent forms of muscular dystrophy. The aims of this study were: 1) to evaluate the prevalence of sleep disordered breathing (SDB) in patients with FSHD; 2) to define the sleep-related respiratory patterns in FSHD patients with SDB; and 3) to find the clinical predictors of SDB. Fifty-one consecutive FSHD patients were enrolled, 23 women, mean age 45.7±12.3 years (range: 26–72). The diagnosis of FSHD was confirmed by genetic tests. All patients underwent medical and neurological evaluations, subjective evaluation of sleep and full-night laboratory-based polysomnography. Twenty patients presented SDB: 13 presented obstructive apneas, four presented REM related oxygen desaturations and three showed a mixed pattern. Three patients needed positive airways pressure. SDB was not related to the severity of the disease. Body mass index, neck circumference and daytime sleepiness did not allow prediction of SDB. In conclusion, the results suggest a high prevalence of SDB in patients with FSHD. The presence of SDB does not depend on the clinical severity of the disease. SDB is often asymptomatic, and no clinical or physical measure can reliably predict its occurrence. A screening of SDB should be included in the clinical assessment of FSHD.

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