Saturday, January 21, 2012

DUX4 Causes Muscle Mayhem in FSHD

DUX4 Causes Muscle Mayhem in FSHD | Quest Magazine Online

Article Highlights:
  • A multicenter research team has provided specific evidence that inappropriate production of DUX4 in muscle is a major contributor to FSH dystrophy.
  • DUX4 disrupts numerous biochemical pathways in muscle, interfering with the ability of muscle cells to develop and thrive.
  • Interfering with DUX4 is a promising strategy for the treatment of FSHD.
  • Measuring DUX4-related biochemical changes in the body could provide researchers with new biomarkers with which to follow disease progression and response to treatment.

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